Inflammatory pseudotumor of ascending colon presenting as PUO: A case report

Inflammatory pseudotumour (inflammatory myofibroblastoma, plasma cell granuloma) is a rare benign lesion in adults and children. It frequently simulates a true neoplasm both clinically and morphologically, presenting a diagnostic and therapeutic dilemma. We herein report a case of a 16 year old girl who presented with pyrexia of unknown origin for almost 4 months before developing a palpable lump in the right iliac fossa. The patient underwent a right hemicolectomy for a presumed ascending colonic neoplasm, and histology revealed that it was an inflammatory pseudotumour. Following resection of the mass there was resolution of constitutional symptoms and normalization of laboratory abnormalities. Since these tumors are self-limiting and have a favorable prognosis, our case review and review of literature suggests the importance of preoperative and intraoperative recognition of this entity, especially if laboratory parameters suggest an inflammatory process.